PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans

CONCLUSION: These results represent the first to confirm the binding of toludesvenlafaxine to DAT in both rats and humans using PET/CT, and its elevation of brain DA level, which may help understand the unique pharmacological and functional effects of triple reuptake inhibitors such as toludesvenlafaxine.GOV IDENTIFIERS: NCT05905120. Registered 14 June 2023. (retrospectively registered).PMID:38587645 | DOI:10.1007/s00259-024-06700-2
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research