A New Insight into Fatty Acid Binding Protein 4 Mechanisms and Therapeutic Implications in Obesity ‐Associated Diseases: A Mini Review

FABP4 (Fatty acid binding protein4), a lipid-binding protein, plays a key role in fat metabolism and is linked to obesity, diabetes, and cardiovascular diseases. Its inhibition could benefit obesity-related conditions, particularly insulin resistance and diabetes. FABP4's release from adipose tissue influences lipid metabolism and insulin function, correlating with BMI and metabolic syndrome, making it a potential target for therapeutic intervention. AbstractFatty acid binding proteins (FABPs), such as FABP4 (aP2, A-FABP), are essential for cellular lipid regulation, membrane –protein interactions, and the modulation of metabolic and inflammatory pathways. FABP4, primarily expressed in adipocytes, monocytes, and macrophages, is integrated into signaling networks that influence immune responses and insulin activity. It has been linked to obesity, inflammation, lipid met abolism, insulin resistance, diabetes, cardiovascular disease, and cancer. Inhibition of FABP4 is emerging as a promising strategy for treating obesity-related conditions, particularly insulin resistance and diabetes. Elevated FABP4 levels in individuals with a BMI above 30 underscore its associatio n with obesity. Furthermore, FABP4 levels are higher not only in the tissues but also in the blood, promoting the onset and development of various cancers. Understanding its broader role reveals involvement in the mechanisms underlying metabolic syndrome, contributing to various metabolic and inflam matory respons...
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Review Source Type: research