Increased Apolipoprotein A1 Expression Correlates with Tumor-Associated Neutrophils and T Lymphocytes in Upper Tract Urothelial Carcinoma

In this study, we examined the relationship between UTUC-derived factors and tumor-associated neutrophils or T lymphocytes. The culture supernatant from UTUC tumor tissue modulated neutrophils to inhibit T cell proliferation. Among the dominant factors secreted by UTUC tumor tissue, apolipoprotein A1 (Apo-A1) exhibited a positive correlation with NLR. Moreover, tumor-infiltrating neutrophils were inversely correlated with tumor-infiltrating T cells. Elevated Apo-A1 levels in UTUC were also inversely associated with the population of tumor-infiltrating T cells. Our findings indicate that elevated Apo-A1 expression in UTUC correlates with tumor-associated neutrophils and T cells. This suggests a potential immunomodulatory effect on neutrophils and T cells within the tumor microenvironment, which may represent therapeutic targets for UTUC treatment.PMID:38534755 | PMC:PMC10968817 | DOI:10.3390/cimb46030139

Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Chih-Chia Chang Chia-Bin Chang Chiung-Ju Chen Chun-Liang Tung Chi-Feng Hung Wei-Hong Lai Cheng-Huang Shen Chang-Yu Tsai Ya-Yan Lai Ming-Yang Lee Shu-Fen Wu Pi-Che Chen Source Type: research