Secular Trends in Peak Bone Mineral Density: The National Health and Nutrition Examination Survey 1999 –2018

This study aimed to investigate secular trends in peak BMD among young adults in the United States. Based on the National Health and Nutrition Examination Survey from 1999–2018, 3,975 males aged 19–28 years and 2370 females aged 31– 40 years were our target population for estimating peak lumbar spine BMD. BMD was measured by dual-energy X-ray absorptiometry. Generalized linear models adjusted for multiple covariates were used to examine the secular trends in peak BMD in males and females, respectively. Secular trends for peak lumbar spine BMD from 1999–2000 to 2017–2018 were not statistically significant in males or females (allPlinear and Pquadratic >  0.05). Similar results were observed in race/ethnicity subgroups (allPlinear andPquadratic >  0.05). However, in stratified analyses by obesity category, peak lumbar spine BMD in obese males and females increased from 1999–2000 to 2009–2010 and then decreased until 2017–2018, while peak lumbar spine BMD in non-obese females decreased from 1999–2000 to 2005–2006 and then increase d until 2017–2018 (allPquadratic <  0.05). Peak lumbar spine BMD was greater in obese males and females than in non-obese males and females up to 2009–2010, but not from 2011–2012 onwards. Overall, there were no significant secular trends in peak lumbar spine BMD. However, secular trends differed between obese and non-obese gro ups.
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research