Cancers, Vol. 16, Pages 1427: Prognostic Indicators of Overall Survival in Hepatocellular Carcinoma Patients Undergoing Liver Resection

Cancers, Vol. 16, Pages 1427: Prognostic Indicators of Overall Survival in Hepatocellular Carcinoma Patients Undergoing Liver Resection Cancers doi: 10.3390/cancers16071427 Authors: Cristina-Paula Ursu Andra Ciocan Ștefan Ursu Răzvan Alexandru Ciocan Claudia Diana Gherman Ariana-Anamaria Cordoș Dan Vălean Rodica Sorina Pop Luminița Elena Furcea Bogdan Procopeț Horia Ștefănescu Emil Ioan Moiș Nadim Al Hajjar Florin Graur Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and the third contributor to malignancy-related deaths worldwide. The hepatic venous pressure gradient (HVPG), transient elastography-liver stiffness measurement (TE-LSM), and the association between TBS (tumor burden score), alpha-fetoprotein levels, and the Child–Pugh classification (TAC score) can serve as valuable prognostic indicators for these patients. Therefore, the main objective of our research was to analyze the prognostic value of the HVPG, TE-LSM, TBS, and TAC scores. An observational and survival study was conducted on 144 subjects. Our findings indicated that HVPG greater than 10 mmHg, AFP surpassing 400 ng/mL, an advanced C–P class, and low TAC score are independent predictors of overall survival. During the multivariate analysis, AFP serum levels and C–P class proved statistically significant. The present study revealed significant differences in overall survival between the two gro...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research