< em > MFSD12 < /em > depletion reduces cystine accumulation without improvement in proximal tubular function in experimental models for cystinosis
In conclusion, MFSD12 mRNA depletion reduced cystine levels in both tested models without improvement of the proximal tubular function in the ctns-/- zebrafish embryo. Additionally, the apparent toxicity of higher mfsd12a TB MO concentrations on the zebrafish development, warrants further evaluation.PMID:38545650 | DOI:10.1152/ajprenal.00014.2024
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tjessa Bondue Laleh Khodaparast Ladan Khodaparast Sara Cairoli Bianca Maria Goffredo Rik Gijsbers Lambertus van den Heuvel Elena Levtchenko Source Type: research
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