Comparative proteomic analysis of the hemolymph and salivary glands of < i > Rhodnius prolixus < /i > and < i > R < /i > . < i > colombiensis < /i > reveals candidates associated with differential lytic activity against < i > Trypanosoma cruzi < /i > Dm28c and < i > T < /i > . < i > cruzi < /i > Y

Conclusions/SignificanceThe lysis resistance observed in the Dm28c strain would be occurring at the DTU I level.T.cruzi I is the DTU with the greatest geographic distribution, from the south of the United States to central Chile and Argentina, a distribution that could be related to resistance to oxidative stress from vectors. Likewise, we can say that lysis against strain Y could occur at the level of DTU II and could be a determinant of the vector inability of these species to transmitT.cruzi II. Future proteomic and transcriptomic studies on vectors and the interactions of the intestinal microbiota with parasites will help to confirm the determinants of successful or failed vector transmission ofT.cruzi DTUs in different parts of the Western Hemisphere.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research