Evidence for the induction of analgesic cross-tolerance between opioid and apelin/APJ systems in male rats

CONCLUSION: Chronic administration of apelin or morphine induces analgesic cross-tolerance that may, in part, be mediated through receptor interactions and downregulation. The demonstrated efficacy of F13-A in these experiments highlights its potential as a novel target for improving pain management through the inhibition of the apelin/APJ signaling pathway, meriting further investigation.PMID:38517751 | DOI:10.15288/jsad.23-00377
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Authors: Source Type: research