On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries

DISCUSSION: We observed substantial heterogeneity for the APOE-harboring 19q13.32 region with TOMM40/APOE/APOC1 genes. The largest risk effect was seen among African Americans, while Asians showed a surprisingly small risk effect.PMID:38563508 | DOI:10.1002/alz.13796

Source: The Journal of Alzheimers Association - April 2, 2024 Category: Psychiatry Authors: Sanghun Lee Julian Hecker Georg Hahn Kristina Mullin Alzheimer's Disease Neuroimaging Initiative (ADNI) Sharon M Lutz Rudolph E Tanzi Christoph Lange Dmitry Prokopenko Source Type: research