Clinical translation of a novel FAPI dimer [ < sup > 68 < /sup > Ga]Ga-LNC1013

CONCLUSION: Dimerization is an effective strategy to produce FAPI derivatives with favorable tumor uptake, long tumor retention, and imaging contrast over its monomeric counterpart. We demonstrated that [68Ga]Ga-LNC1013, the lead compound without any piperazine moiety, had superior diagnostic potential over [68Ga]Ga-FAPI-46 and 18F-FDG, suggesting the future potential of LNC1013 for radioligand therapy of FAP-positive cancers.PMID:38561515 | DOI:10.1007/s00259-024-06703-z

Source: Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Yue Tan Jian Li Tianzhi Zhao Ming Zhou Kehuang Liu Shijun Xiang Yongxiang Tang Vivianne Jakobsson Pengfei Xu Xiaoyuan Chen Jingjing Zhang Source Type: research