Detecting T-cell clonal expansions and quantifying clone survival using deep profiling of immune repertoires

In this study, we report a bioinformatic method for quantifying the T-cell repertoire dynamics from TCR sequencing data. We demonstrate its utility by measuring the T-cell repertoire stability in healthy donors, by quantifying the effect of donor lymphocyte infusion (DLI), and by tracking the fate of the different T-cell subsets in HSCT patients and the expansion of pathogen-specific clones in vaccinated individuals.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research