Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson ’s disease through Mfn2-cGAS signaling

Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson ’s disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuro...

Source: Journal of Neuroinflammation - April 2, 2024 Category: Neurology Authors: Min Wang, Tian Tian, Hong Zhou, Si-Yuan Jiang, Ying-Ying Jiao, Zhu Zhu, Jiang Xia, Jian-Hua Ma and Ren-Hong Du Tags: Research Source Type: research