The interaction effect of dietary selenium intake and the < em > IL10 < /em > rs1800871 polymorphism on the risk of colorectal cancer: a case ‒control study in Korea

Br J Nutr. 2024 Mar 21:1-23. doi: 10.1017/S0007114524000345. Online ahead of print.ABSTRACTThe importance of selenium in human health has received much attention due to its antioxidant properties when it is consumed at an appropriate level. However, the existing evidence is limited to obtain an effective conclusion for colorectal cancer (CRC). Notably, an adequate intake of selenium was reported for Koreans. Furthermore, cytokine secretion and immune function may be affected by dietary selenium. Our study aimed to explore whether selenium potentially reduces CRC risk and whether the IL10 rs1800871 polymorphism has an effect on this association. We designed a case‒control study with 1,420 cases and 2,840 controls. A semiquantitative food frequency questionnaire was used to obtain information on selenium intake. We determined IL10 rs1800871 through genetic analysis. Different models were developed to explore selenium intake related to CRC risk by calculating odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression. A reduced risk of CRC was found as selenium intake increased, with an OR (95% CI) of 0.44 (0.35-0.55) (p for trend <0.001). However, this association seems to be allele specific and only present among risk variant allele carriers (GA/GG) with a significant interaction between dietary selenium and IL10 rs1800871 (P interaction=0.043). We emphasized that a reduction in CRC risk is associated with appropriate selenium intake. How...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Source Type: research