Clinical characteristics, outcomes and prognostic factors in KRAS mutant lung cancers: experience from a tertiary care cancer center in India

CONCLUSION: This is the largest dataset of KRAS mutant lung cancers from India. Brain metastases were higher in patients with G12C mutations and associated with poorer PFS and OS. G12C mutation and PS ≥ 2 were also associated with inferior PFS and OS. Experience with targeted therapy for KRAS mutations remains an area of future exploration due to the unavailability of these agents in India.PMID:38439805 | PMC:PMC10911678 | DOI:10.3332/ecancer.2024.1674

Source: Ecancermedicalscience - March 5, 2024 Category: Cancer & Oncology Authors: Vanita Noronha Laboni Sarkar Vijay Patil Nandini Menon Minit Shah Akash Pawar Oindrila Roy Chowdhury Omshree Shetty Anuradha Chougule Pratik Chandrani Rajiv Kaushal Trupti Pai Amit Janu Nivedita Chakrabarty Kumar Prabhash Source Type: research