Serum potassium abnormalities, renin-angiotensin-aldosterone system inhibitor discontinuation, and clinical outcomes in patients with chronic cardiovascular, metabolic, and renal conditions: A population-based analysis

CONCLUSION: In this large, observational study, hyperkalemia was linked to a greater likelihood of discontinuing RAASIs. Down-titration of RAASI was independently associated with unfavorable clinical outcomes such as hospitalization and specially mortality. Although the observational nature of the study, these findings underscore the importance of preventing circumstances that may lead to RAASI down-titration, such as hyperkalemia, as well as preventing hospitalizations and mortality, to ensure RAASI benefits.PMID:38548513 | DOI:10.1016/j.ejim.2024.03.021

Source: European Journal of Internal Medicine - March 28, 2024 Category: Internal Medicine Authors: Santiago Jim énez-Marrero Miguel Cainzos-Achirica David Monterde Emili Vela Cristina Enjuanes Sergi Yun Alberto Garay Pedro Moliner Miriam Corbella S ílvia Jovells-Vaqué L ídia Alcoberro Alexandra Pons-Riverola Raul Ramos-Polo Herminio Morillas Joan A Source Type: research