Internal m 6 A and m 7 G RNA modifications in hematopoietic system and acute myeloid leukemia
Chin Med J (Engl). 2024 Mar 28. doi: 10.1097/CM9.0000000000003073. Online ahead of print.ABSTRACTEpitranscriptomics focuses on RNA modifications-mediated post-transcriptional regulation of gene expression. The current decade has witnessed tremendous progress in understanding the landscapes and biological functions of RNA modifications as prompted by potent analytical approaches. The hematopoietic system provides a lifelong supply of blood cells, and gene expression is tightly modulated during the differentiation of hematopoietic stem cells (HSCs). Dysregulation of gene expression during hematopoiesis may lead to severe disorders, including acute myeloid leukemia (AML). Emerging evidence has indicated the involvement of mRNA modification system in normal hematopoiesis and AML pathogenesis, which led to the accelerating development of small-molecule inhibitors targeting N6-methyladenosine (m 6 A) modification machinery for treatment. Here, we summarize the latest findings and address the state-of-the-art knowledge on the role of m 6 A and N7-methylguanine (m 7 G) in both physiological and pathological conditions in the hematopoietic system. Furthermore, we discuss the therapeutic potential and limitations of cancer treatment targeting m 6 A.PMID:38545694 | DOI:10.1097/CM9.0000000000003073
Source: Chinese Medical Journal - Category: General Medicine Authors: Xiaoxu Zhang Yanni Ma Jia Yu Rui Su Xiaoshuang Wang Source Type: research
More News: Acute Leukemia | Acute Myeloid Leukemia | Cancer | Cancer & Oncology | China Health | General Medicine | Genetics | Leukemia | Stem Cell Therapy | Stem Cells