Efficacy of autologous and allogeneic hematopoietic cell transplantation in adults with acute promyelocytic leukemia: results of a systematic review and meta-analysis

Acute promyelocytic leukemia (APL) represents a distinct subtype of acute myeloid leukemia, accounting for approximately 15% of cases in the United States1. Diagnosis of APL requires confirmation of the presence of a reciprocal translocation involving the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor alpha (RARA) gene on chromosome 17 t(15;17), so called APL with PML::RARA fusion2, 3. Other variants of APL with different chromosomal aberrations have been described less frequently4-6.

Source: Biology of Blood and Marrow Transplantation - March 28, 2024 Category: Hematology Authors: Razan Mohty, Tea Reljic, Farah Yassine, Christian Kettaneh, Dua Al-Husni, Katelyn Keller, Talha Badar, Hemant Murthy, James Foran, Ambuj Kumar, Mohamed A. Kharfan-Dabaja Source Type: research