Tumor associated macrophages as key contributors and targets in current and future therapies for melanoma

We present a review of the most up-to-date literatureavailable on PubMed, focussing on studies from within the last 10 years. We also include data from ongoing and recent clinical trials targeting macrophages in melanoma listed on clinicaltrials.gov.EXPERT OPINION: Understanding the multifaceted role of macrophages in melanoma, including their interactions with immune and cancer cells, the influence of current therapies on macrophage phenotype and functions and how macrophages could be targeted with novel treatment approaches, are all critical for improving outcomes for patients with melanoma.PMID:38533720 | DOI:10.1080/1744666X.2024.2326626

Source: Expert Review of Clinical Immunology - March 27, 2024 Category: Allergy & Immunology Authors: Shabana Habib Gabriel Osborn Zena Willsmore Min Waye Chew Sophie Jakubow Amanda Fitzpatrick Yin Wu Khushboo Sinha Hawys Lloyd-Hughes Jenny L C Geh Alastair D MacKenzie-Ross Sean Whittaker Victoria Sanz-Moreno Katie E Lacy Sophia N Karagiannis Rebecca Adam Source Type: research