Small Intestine Bacterial Overgrowth is associated with increased < i > Campylobacter < /i > and epithelial injury in duodenal biopsies of Bangladeshi children

by Shah Mohammad Fahim, Jeffrey R. Donowitz, Ekaterina Smirnova, Ning-Juin Jan, Subhasish Das, Mustafa Mahfuz, S. M. Abdul Gaffar, William A. Petri Jr, Chelsea Marie, Tahmeed Ahmed Small intestine bacterial overgrowth (SIBO) has been associated with enteric inflammation, linear growth stunting, and neurodevelopmental delays in children from low-income countries. Little is known about the histologic changes or epithelial adherent microbiota associated with SIBO. We sought to describe these relationships in a cohort of impoverished Bangladeshi children. Undernourished 12-18-month-old children underwent both glucose hydrogen breath testing for SIBO and duodenoscopy with biopsy. Biopsy samples were subject to both histological scoring and 16s rRNA sequencing. 118 children were enrolled with 16s sequencing data available on 53. Of 11 histological features, we found that SIBO was associated with one, enterocyte injury in the second part of the duodenum (R = 0.21, p = 0.02). SIBO was also associated with a significant increase inCampylobacter by 16s rRNA analysis (Log 2-fold change of 4.43; adjusted p = 1.9 x 10−6). These findings support the growing body of literature showing an association between SIBO and enteric inflammation and enterocyte injury and further delineate the subgroup of children with environmental enteric dysfunction who have SIBO. Further, they show a novel association between SIBO andCampylobacter. Mechanistic work is needed to understand the relationship betw...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research