Ropivacaine as a novel AKT1 specific inhibitor regulates the stemness of breast cancer

CONCLUSION: Our finding revealed that local anesthetic ropivacaine attenuated breast cancer stemness through AKT1/GGT1/NF-κB signaling pathway, suggesting the potential clinical value of ropivacaine in breast cancer treatment.PMID:38523299 | PMC:PMC10962119 | DOI:10.1186/s13046-024-03016-9

Source: Clinical Breast Cancer - March 25, 2024 Category: Cancer & Oncology Authors: Lin Ding Hui Jiang Qiangwei Li Qiushuang Li Tian-Tian Zhang Limeng Shang Bin Xie Yaling Zhu Keshuo Ding Xuanming Shi Tao Zhu Yong Zhu Source Type: research