A systematic review and meta-analysis on the efficacy of vaccination against colibacillosis in broiler production

by Surya Paudel, Ilias Apostolakos, Ronald Vougat Ngom, Giuditta Tilli, Helena C. de Carvalho Ferreira, Alessandra Piccirillo Colibacillosis, a disease caused byEscherichia coli in broiler chickens has serious implications on food safety, security, and economic sustainability. Antibiotics are required for treating the disease, while vaccination and biosecurity are used for its prevention. This systematic review and meta-analysis, conducted under the COST Action CA18217 —European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT), aimed to assess the efficacy ofE.coli vaccination in broiler production and provide evidence-based recommendations. A comprehensive search of bibliographic databases, including, PubMed, CAB Abstracts, Web of Science and Agricola, yielded 2,722 articles. Following a defined protocol, 39 studies were selected for data extraction. Most of the studies were experimental infection trials, with only three field studies identified, underscoring the need for more field-based research. The selected studies reported various types of vaccines, including killed (n = 5), subunit (n = 8), outer membrane vesicles/protein-based (n = 4), live/live-attenuated (n = 16), and CpG oligodeoxynucleotides (ODN) (n = 6) vaccines. The risk of bias assessment revealed that a significant proportion of studies reporting mortality (92.3%) or feed conversion ratio (94.8%) as outcomes, had “unclear” regarding bias. The meta-analysis, focused on live-attenu...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research