Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats

In conclusion, ESA alleviates retinopathy in T1DM rats by suppressing REDD1-associated degradation and inhibiting the Nrf2/antioxidant axis.PMID:38503237 | DOI:10.1016/j.biopha.2024.116461

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2024 Category: Drugs & Pharmacology Authors: Nasser A Alsabaani Kawther Amawi Samy M Eleawa Wisam Nabeel Ibrahim Walid Aldhaban Ahmad Mohammad Alaraj Badr Alkhalaf Waqas Sami Hisham Alshaikhli Mahmoud A Alkhateeb Source Type: research