Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells

Conclusion. Taken together, the present study indicates that cortisol may interact with ER stress and hypoxia in the regulation of ER stress dependent XBP1 and DNAJB9 mRNA expression as well as INSR and its signaling and that this corticosteroid hormone modified the impact of hypoxia and especially tunicamycin on the expression of most studied genes in HEK293 cells. These data demonstrate molecular mechanisms of glucocorticoids interaction with ER stress and insulin signaling at the cellular level.PMID:38345493 | DOI:10.2478/enr-2024-0001

Source: Endocrine Regulations - February 12, 2024 Category: Endocrinology Authors: Dmytro O Minchenko Olena O Khita Yuliia M Viletska Myroslava Y Sliusar Olha V Rudnytska Halyna E Kozynkevych Borys H Bezrodnyi Yevgen P Khikhlo Oleksandr H Minchenko Source Type: research