Cancers, Vol. 16, Pages 1204: Immunoprofiles and Oncologic Outcomes of 15 Patients with Androgen Receptor-Positive Salivary Duct Carcinoma

Conclusion: Despite only including AR+ SDC of the parotid, immunoprofiles, such as expression of HER-2, were highly variable, highlighting the potential to tailor systemic regimens based on individual histologic profiles in the future. Studies with larger patient numbers using tumor-specific molecular profiling and tumor heterogeneity analyses are justified to better understand the biology of these tumors. Molecularly informed treatment approaches, including the potential use of AR- and HER-2/Neu-directed therapies upfront in the definitive setting, may hold future promise to further improve outcomes for these patients.

Source: Cancers - March 19, 2024 Category: Cancer & Oncology Authors: Emile Gogineni Blake E. Sells Khaled Dibs Sachin R. Jhawar Catherine T. Haring Abberly L. Limbach David J. Konieczkowski Sung J. Ma Simeng Zhu Sujith Baliga Darrion L. Mitchell John C. Grecula Marcelo Bonomi Priyanka Bhateja Matthew O. Old Nolan B. Seim S Tags: Article Source Type: research