Effect of oral naloxone on opioid-induced constipation in methadone maintenance treatment patients, a double-blind, placebo-control, clinical trial

ConclusionOral naloxone at doses of 0.5 and 2  mg/day was significantly more effective than placebo on OIC in MMT. However, the dose of 4 mg induced intolerable OWS.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research