Cancers, Vol. 16, Pages 1187: Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M

Cancers, Vol. 16, Pages 1187: Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M Cancers doi: 10.3390/cancers16061187 Authors: Takuya Yoshimura Yuka Hirano Taiji Hamada Seiya Yokoyama Hajime Suzuki Hirotaka Takayama Hirono Migita Takayuki Ishida Yasunori Nakamura Masahiro Ohsawa Akihiro Asakawa Kiyohide Ishihata Akihide Tanimoto Major advances have been made in cancer treatment, but the prognosis for elderly cancer patients with sarcopenia and frailty remains poor. Myokines, which are thought to exert preventive effects against sarcopenia, have been reported to be associated with the prognosis of various cancers, but their effect on head and neck squamous cell carcinoma (HNSCC) is unknown. The aim of this study was to clarify the influence of exercise on the control of HNSCC and to examine the underlying mechanism involved. Mice were injected with HSC-3-M3 cells, a human cell line of highly metastatic and poorly differentiated tongue cancer, at the beginning of the study. Just prior to transplantation, blood was collected from the mice, and the levels of myokines were measured by ELISA. Oncostatin M (OSM), a selected myokine, was added to HSC-3-M3 cells, after which the cell proliferation ability, cell cycle, and protein expression were analyzed in vitro. Tumor cell viability was lower (control: 100%, exercise: 75%), tumors were smaller (control: 26.2 mm3, exercise: 6.4 mm3), and survival was longer in the exercis...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research