Hydrogen sulfide improves endothelial barrier function by modulating the ubiquitination degradation of KLF4 through TRAF7 S-sulfhydration in diabetic aorta

In conclusion, our research demonstrates that H2S plays a pivotal role in regulating S-sulfhydration of TRAF7 at Cys327. This regulation effectively inhibits the ubiquitin-mediated degradation of KLF4, resulting in an upregulation of VE-cadherin levels. This molecular mechanism contributes to the prevention of endothelial barrier damage.PMID:38479633 | DOI:10.1016/j.freeradbiomed.2024.02.024

Source: Free Radical Biology and Medicine - March 13, 2024 Category: Biology Authors: Qianzhu Li Jiaxin Kang Ning Liu Jiayi Huang Xueya Zhang Kemiao Pang Shiwu Zhang Mengyi Wang Yajun Zhao Shiyun Dong Hongxia Li Dechao Zhao Fanghao Lu Weihua Zhang Source Type: research