Biomarker-Driven Radiation Therapy Dose Reduction after Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer

HPV-driven oropharyngeal squamous cell cancer (OPSCC) has a high cure rate and a high burden of treatment-related toxicities. Transoral robotic surgery (TORS) is a treatment option for patients with early-stage disease. Most patients will be recommended adjuvant RT. ECOG 3311 was a phase 2 trial demonstrating that patients with intermediate pathologic risk factors treated with 50 Gy of adjuvant RT had similar survival as those receiving the current standard 60 Gy of adjuvant RT. However, 50 Gy is still associated with meaningful toxicity, specifically with respect to impaired swallowing function.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: 103 Source Type: research