Investigating NRF2-Mediated Radioresistance in HPV-Negative Head and Neck Squamous Cell Carcinoma Preclinical Models

Head and neck squamous cell carcinomas (HNSCC) that are not driven by human papillomavirus (HPV) are associated with a higher likelihood of treatment resistance and recurrence compared to HPV-positive HNSCC. There are currently no genomic-guided treatments for HPV-negative HNSCC, meaning that patients do not benefit from precision medicine approaches. Thus, it is critical to understand the mechanisms underlying HNSCC progression to identify molecular targets and better stratify therapeutic options for patients.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: 222 Source Type: research