Meta-analysis of the Selected Genetic Variants in Immune-Related Genes and Multiple Sclerosis Risk

AbstractPrevious studies have suggested that certain variants in immune-related genes may participate in the pathogenesis of multiple sclerosis (MS), including rs17824933 in theCD6 gene, rs1883832 in theCD40 gene, rs2300747 in theCD58 gene, rs763361 in theCD226 gene, rs16944 in theIL-1 β gene, rs2243250 in theIL-4 gene, and rs12722489 and rs2104286 in theIL-2R α gene. However, the results remained inconclusive and conflicting. In view of this, a comprehensive meta-analysis including all eligible studies was conducted to investigate the association between these 8 selected genetic variants and MS risk. Up to June 2023, 64 related studies were finally included in this meta-analysis. The odds ratios (ORs) and corresponding 95% confidence intervals (CIs) calculated by the random-effects model were used to evaluate the strength of association. Publication bias test, sensitivity analyses, and trial sequential analysis (TSA) were conducted to examine the reliability of statistical results. Our results indicated that rs17824933 in theCD6 gene, rs1883832 in theCD40 gene, rs2300747 in theCD58 gene, rs763361 in theCD226 gene, and rs12722489 and rs2104286 in theIL-2R α gene may serve as the susceptible factors for MS pathogenesis, while rs16944 in theIL-1 β gene and rs2243250 in theIL-4 gene may not be associated with MS risk. However, the present findings need to be confirmed and reinforced in future studies.
Source: Molecular Neurobiology - Category: Neurology Source Type: research