An Example of Antihypertensive Drug Discovery Based on TRPV2 Biochemistry

This study represents a very important starting point for using this TRPV2 activation as a therapeutic strategy against diseases that cause excessive vasoconstriction, such as hypertension." In a second study, the research group used computational techniques to identify a set of 270 molecules that, due to their physical and chemical characteristics, could interact with TRPV2, and grouped them by families according to how each of these molecules would bind to TRPV2. Then, by expressing the TRPV2 protein in yeast, a screening system was designed to test its effects. This made it possible to find a molecule (4-piperidin-1-sulfonyl-benzoic acid) capable of activating this protein more powerfully than the only drug known so far to do so: probenecid. "The activation of TRPV2 produced by the new molecule identified in this study has a very interesting vasodilator effect that could be used in the future as an antihypertensive therapy." Link: https://www.uab.cat/web/newsroom/news-detail/new-therapeutic-approaches-for-hypertension-through-trpv2-proteins-1345830290613.html?detid=1345911637048
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs