Determinants of V ̇+O2peak Changes After Aerobic Training in Coronary Heart Disease Patients
This study aimed to highlight the ventilatory and circulatory determinants of
changes in ˙VO2peak after exercise-based cardiac rehabilitation (ECR)
in patients with coronary heart disease (CHD). Eighty-two CHD patients
performed, before and after a 3-month ECR, a cardiopulmonary exercise testing
(CPET) on a bike with gas exchanges measurements (˙VO2peak, minute
ventilation, i. e., ˙VE), and cardiac output (Q˙c). The arteriovenous difference
in O2 (C(a-v¯)O2) and the alveolar capillary gradient in
O2 (PAi-aO2) were calculated using Fick’s laws. Oxygen
uptake efficiency slope (OUES) was calculated. A 5.0% cut off was applied for
differentiating non- (NR: ˙VO2<0.0%), low (LR: 0.0≤
∆˙VO2<5.0%), moderate (MR: 5.0≤∆˙VO2 < 10.0%),
and high responders (HR: ∆˙VO2≥10.0%) to ECR. A total of 44% of
patients were HR (n=36), 20% MR (n=16), 23% LR (n=19), and 13% NR (n=11). For
HR, the ˙VO2peak increase (p<0.01) was associated with increases
in ˙VE (+12.8±13.0 L/min, p<0.01),
(+1.0±0.9 L/min, p<0.01), and C(a-v¯)O2
(+2.3±2.5 mLO2/100 mL, p<0.01). MR patients were characterized
by+6.7±19.7 L/min increase in ˙VE (p=0.04) and+0.7±1.0 L/min of Q˙c (p<0.01). ECR induced decreases in
˙VE (p=0.04) and C(a-v¯)O2 (p<0.01) and a Q˙c increa...
Source: International Journal of Sports Medicine - Category: Sports Medicine Authors: Girault, Axel Lepr être, Pierre-Marie Trachsel, Lukas-Daniel Besnier, Florent Boidin, Maxime Lalong é, Julie Juneau, Martin Bherer, Louis Nigam, Anil Gayda, Mathieu Tags: Clinical Sciences Source Type: research
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