Depressive symptoms and plasma markers of Alzheimer's disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies

Depression has been coined as one of the main risk factors for Alzheimer's disease (AD) dementia (1-4). One longitudinal study in older adults found that with every increasing point on a depressive symptom scale, the risk of AD increased by 19% (5). Another study found that high levels of depressive symptoms were associated with a 50% increased risk of dementia (6). However, the mechanistic relationship between the two is not yet fully understood. Some studies have highlighted depression as a possible risk factor while others suggest that depression may in fact be an early manifestation of underlying AD (7,8).

Source: The American Journal of Geriatric Psychiatry - March 11, 2024 Category: Geriatrics Authors: Emma L. Twait, Maria Kamarioti, Inge M.W. Verberk, Charlotte E. Teunissen, Astrid C.J. Nooyens, W.M. Monique Verschuren, Pieter Jelle Visser, Martijn Huisman, Almar A.L. Kok, P. Eline Slagboom, Marian Beekman, Dina Vojinovic, Nico Lakenberg, M. Arfan Ikra Tags: Regular Research Article Source Type: research