Interobserver Variability and Challenges in Intraoperative Frozen Section Evaluation of Pancreatic Margins in Pancreatectomy Specimens

CONCLUSIONS: We showed excellent interobserver agreement among gastrointestinal pathologists for diagnosis of adenocarcinoma on frozen sections of pancreatic margins with marked chronic pancreatitis. Missed adenocarcinoma at the margin was mainly caused by freezing or cautery artifacts or by overlooking a tiny focus of perineural invasion in a background of marked chronic pancreatitis. The evaluation of deeper levels led to perfect agreement.PMID:38182140

Source: Annals of Clinical and Laboratory Science - January 5, 2024 Category: Laboratory Medicine Authors: Sadhna Dhingra Melissa W Taggart Wai Chin Foo Asif Rashid Maria Luisa Machado Heredia Sarah B May George Van Buren William E Fisher Huamin Wang Source Type: research