Delays in latencies of median-nerve evoked magnetic fields in patients with succinic semialdehyde dehydrogenase deficiency

CONCLUSIONS: The SEF latencies are delayed in patients with SSADHD compared with healthy controls and disease controls.SIGNIFICANCE: This is the first study that compares conduction velocities in the somatosensory pathway in SSADHD, an inherited disorder of GABA metabolism. The longer peak latency implying slower conduction velocity supports the hypothesis that myelin sheath thickness is decreased in SSADHD.PMID:38447494 | DOI:10.1016/j.clinph.2024.02.010

Source: Clinical Neurophysiology - March 6, 2024 Category: Neurology Authors: Teppei Matsubara Sheraz Khan Padmavathi Sundaram Steven Stufflebeam Deniz Aygun Melissa DiBacco Jean-Baptiste Roullet Phillip L Pearl Yoshio Okada Source Type: research