Identification of TMZ resistance-associated histone post-translational modifications in glioblastoma using multi-omics data

CONCLUSIONS: The increase in H3K9ac appears to enhance the recruitment of the transcription factor SP1 to its binding sites within the MGMT locus, consequently upregulating MGMT expression and driving TMZ resistance in GBM.PMID:38448295 | DOI:10.1111/cns.14649

Source: CNS Neuroscience and Therapeutics - March 6, 2024 Category: Neuroscience Authors: Liguo Ye Lingui Gu Yaning Wang Hao Xing Pengtao Li Xiaopeng Guo Yu Wang Wenbin Ma Source Type: research