ForePass endoscopic bypass device for obesity and insulin resistance--metabolic treatment in a swine model

WHAT IS ALREADY KNOWN ON THIS SUBJECTMetabolic surgery (MS) is a highly effective treatment for obesity and type 2 diabetes, leading to sustained weight loss over time. Notably, MS can reverse several obesity-related comorbidities such as chronic inflammation, hypertension and non-alcoholic fatty liver diseases, including nonalcoholic steatohepatitis (NASH). WHAT ARE THE NEW FINDINGS We showed that ForePass influences glucose kinetics, enhancing insulin-mediated whole-body glucose uptake, hepatic insulin sensitivity and insulin clearance. Moreover, ForePass modifies plasma metabolites and the variety and structure of faecal microbiota, increasing bacteria that beneficially impact glucose metabolism. HOW MIGHT IT IMPACT ON CLINICAL PRACTICE IN THE FORESEEABLE FUTURE As a highly effective procedure, ForePass can be considered an incisionless alternative to traditional surgical procedures. ForePass can also be used for high-risk patients who are ineligible for MS, reject a surgical approach, prefer a bridge to MS, or as...

Source: Gut - March 7, 2024 Category: Gastroenterology Authors: Angelini, G., Galvao Neto, M., Boskoski, I., Caristo, M. E., Russo, S., Proto, L., Previti, E., Olsson, L., Aggarwal, H., Pezzica, S., Ferrari, E., Bove, V., Genco, A., Bornstein, S., Tremaroli, V., Gastaldelli, A., Mingrone, G. Tags: Open access, Gut Endoscopy news Source Type: research