Non-homologous End-joining Genotype, mRNA Expression, and DNA Repair Capacity in Childhood Acute Lymphocytic Leukemia

CONCLUSION: Our study identified significant associations between XRCC4 rs3734091, rs28360071, XRCC5 rs828907, and XRCC6 rs5751129 genotypes and childhood ALL. Notably, lower transcriptional expression and reduced precise NHEJ repair capacity were observed in patients carrying the C allele of XRCC6 rs5751129. Further investigations are required to gain deeper insights into childhood ALL development.PMID:38423600 | PMC:PMC10905275 | DOI:10.21873/cgp.20436

Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Chao-Chun Chen Wen-Shin Chang Jen-Sheng Pei Chien-Chung Kuo Chung-Hsing Wang Yun-Chi Wang Pei-Chen Hsu Jie-Long He Jian Gu DA-Tian Bau Chia-Wen Tsai Source Type: research