Prostaglandin E2 Affects Mitochondrial Function in Adult Mouse Cardiomyocytes and Hearts

The bioactive lipid Prostaglandin E2 (PGE2) signals through 4 known G-protein-coupled receptor subtypes (EP1-EP4) to elicit a variety of physiologic and pathologic effects that are mediated through diverse signaling pathways. The heart expresses all four receptor subtypes although EP3 and EP4 are the most abundant and share similar affinities for PGE2 [1 –4]. Importantly, we have previously reported that the expression of EP3 and EP4 receptors is altered with disease states such as hypertension and myocardial infarction [5,6], so that signaling via EP3 predominates.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research