Proliferation and migration of PC-3 prostate cancer cells is counteracted by PPAR γ-cladosporol binding-mediated apoptosis and a decreased lipid biosynthesis and accumulation

CONCLUSION: This is the first work, to our knowledge, in which the role of cladosporols A and B was disclosed in prostate cancer cells. Importantly, the present study highlighted the potential of cladosporols as new therapeutical tools, which, interfering with cell proliferation and lipid pathway dysregulation, may control prostate cancer initiation and progression.PMID:38428827 | DOI:10.1016/j.bcp.2024.116097

Source: Biochemical Pharmacology - March 1, 2024 Category: Drugs & Pharmacology Authors: Roberta Rapuano Alessio Riccio Antonella Mercuri Jessica Raffaella Madera Sabrina Dallavalle Salvatore Moricca Angelo Lupo Source Type: research