Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease

CONCLUSIONS: Our results characterize the electrophysiological abnormalities associated with L casei cell wall extract-induced KD and show that IL-1Ra is more effective in preventing KD-induced myocardial dysfunction and arrhythmias than anti-TNFα therapy. These findings support the advancement of clinical trials using IL-1Ra in patients with KD.PMID:38385289 | DOI:10.1161/ATVBAHA.123.320382

Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 22, 2024 Category: Cardiology Authors: Thassio Mesquita Yen-Nien Lin Shuang Chen Youngho Lee Rodrigo Miguel-Dos-Santos Asli E Atici Michael C Fishbein Magali Noval Rivas Moshe Arditi Eugenio Cingolani Source Type: research