GSE134588 Maternal folic acid overconsumption in mice leads to sex-specific transcriptional alterations in cerebral cortex in offspring

Contributors : Marta Cos ín-Tomás ; Yan Luan ; Daniel Leclerc ; Olga Maleysheva ; Nidia Lauzon ; Renata H Bahous ; Karen Christensen ; Marie Caudill ; Rima RozenSeries Type : Expression profiling by arrayOrganism : Mus musculusRecent concerns have been raised regarding high folate intake during pregnancy and lactation, particularly following food forti fication and increased vitamin supplement use. Epidemiologic studies have shown that high folic acid (FA) intake can negatively impact motor and neurocognitive development in offspring.We used microarray to investigate the mechanisms by which a supplemented diet containing 5-fold higher FA than recommended (FASD) affects brain function in both male and female offspring.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research