Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations

ConclusionAmiodarone hepatotoxicity resembles that seen in alcohol related liver injury, with fatty infiltration and inflammation. Dronedarone is less predictable, typically without fat and with a shorter latency of use before presentation. These differences may be explained, in part, by the differing pharmacokinetics of the two drugs leading to different mechanisms of hepatotoxicity.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research