Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors

Trends Endocrinol Metab. 2024 Feb 29:S1043-2760(24)00032-8. doi: 10.1016/j.tem.2024.02.003. Online ahead of print.ABSTRACTInflammation plays an essential role and is a common feature in the pathogenesis of many chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 (SGLT2) inhibitors achieve their much-acclaimed clinical benefits largely remain unknown. In this review, we detail the systemic and tissue- or organ-specific anti-inflammatory effects of SGLT2 inhibitors using evidence from animal and human studies. We discuss the potential pathways through which SGLT2 inhibitors exert their anti-inflammatory effects, including oxidative stress, mitochondrial, and inflammasome pathways. Finally, we highlight the need for further investigation of the extent of the contribution of the anti-inflammatory effects of SGLT2 inhibition to improvements in cardiometabolic and renal outcomes in clinical studies.PMID:38423898 | DOI:10.1016/j.tem.2024.02.003
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research