Modulation of the Sirtuin-1 signaling pathway in doxorubicin-induced nephrotoxicity (synergistic amelioration by resveratrol and pirfenidone)

In conclusion, DOX exposure leads to renal toxicity by inducing renal degeneration, oxidative stress, and apoptosis. Administration of either resveratrol or Pirfenidone counteracted these changes and protected the kidney against DOX-induced renal damage.PMID:38412579 | DOI:10.1016/j.tice.2024.102330

Source: Tissue and Cell - February 27, 2024 Category: Cytology Authors: Samia Mahmoud Manawy Eman Mohamed Faruk Rabab Fawzy Hindawy Mahmoud M Hassan Diaa M G Farrag Mansour A E Bashar Hanan Fouad Rania Abubaker Bagabir Dina Allam Abdelmaksoud Hassan Ahmed Mohammed Zaazaa Mohamed Ghazy Attia Hablas K Mostafa Kamal Source Type: research