Risk adaptive planning with biology-based constraints may lead to higher tumor control probability in tumors of the canine brain: A planning study
Classical radiation protocols are guided by physical dose delivered homogeneously over the target. Protocols are chosen to keep normal tissue complication probability (NTCP) at an acceptable level. Organs at risk (OAR) adjacent to the target volume could lead to underdosage of the tumor and a decrease of tumor control probability (TCP). The intent of our study was to explore a biology-based dose escalation: by keeping NTCP for OAR constant, radiation dose was to be maximized, allowing to result in heterogeneous dose distributions.
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Stephan Radonic, Uwe Schneider, J ürgen Besserer, Valeria S. Meier, Carla Rohrer Bley Tags: Original paper Source Type: research