Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats

In conclusion, the enhancement of Glu-NMDA receptor transmission in the hippocampal DG contributes to the impairment of spatial learning and memory in DIO rats, maybe via the modulation of CaMKII-CREB-BDNF signaling pathway.PMID:38416255 | DOI:10.1007/s00424-024-02924-1

Source: Pflugers Archiv : European Journal of Physiology - February 28, 2024 Category: Physiology Authors: Dingding Lv Bin Xiao Huaying Liu Linping Wang Yingshun Li Yin Hua Zhang Qinghua Jin Source Type: research