HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells

In conclusion, CLPP increases DDP resistance in ovarian cancer by inhibiting mitophagy and promoting cellular stress. Meanwhile, HSPA8 promotes the degradation of CLPP protein by regulating its stability.PMID:38419499 | DOI:10.3724/abbs.2023246

Source: Acta Biochimica et Biophysica Sinica - February 29, 2024 Category: Biochemistry Authors: Xinxin Kou Xiaoxia Yang Zheng Zhao Lei Li Source Type: research