Heart Failure and Hypertrophic Cardiomyopathy —Looking Back on Decades of Remarkable Progress

Hypertrophic cardiomyopathy (HCM) is a complex genetic disease that results in pathologic left ventricular hypertrophy with associated heart failure. From its earliest descriptions as “functional” aortic stenosis due to severe ventricular septal hypertrophy,1 there has been tremendous advance in our biologic understanding of HCM. We now understand that clinical HCM can manifest with symptomatic heart failure in a highly diverse way ranging from dynamic left ventricular outflo w tract obstruction1 to nonobstructive HCM with restrictive cardiomyopathy2 or rarely with ventricular arrhythmia and sudden death.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Editorial Source Type: research