Longitudinal analysis of post-acute chikungunya-associated arthralgia in children and adults: A prospective cohort study in Managua, Nicaragua (2014 –2018)

by Colin M. Warnes, Fausto Andres Bustos Carrillo, Jose Victor Zambrana, Brenda Lopez Mercado, Sonia Arguello, Oscarlette Ampi é, Damaris Collado, Nery Sanchez, Sergio Ojeda, Guillermina Kuan, Aubree Gordon, Angel Balmaseda, Eva Harris Chikungunya can result in debilitating arthralgia, often presenting as acute, self-limited pain, but occasionally manifesting chronically. Little is known about differences in chikungunya-associated arthralgia comparing children to adults over time. To characterize long-term chikungunya-associated arthralgia, we recruited 770 patients (105 0 –4 year old [y/o] children, 200 5–9 y/o, 307 10–15 y/o, and 158 16+ y/o) with symptomatic chikungunya virus infections in Managua, Nicaragua, during two consecutive chikungunya epidemics (2014–2015). Participants were assessed at ~15 days and 1, 3, 6, 12, and 18 months post-fever onset. Foll owing clinical guidelines, we defined participants by their last reported instance of arthralgia as acute (≤10 days post-fever onset), interim (>10 and
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research